OSCAR Dine Healthy Eating Project

We undertook a healthy eating project with a holiday club in Nottingham. 

Here is the link to our DINE project report.

2011 Research Profile

Title: Dr    

Family/Surname/Last Name: Basten                        

First Names:    Graham            

Current Job title:    Associate Head of School                        

Faculty/Institute: HLS

Department/School: Allied Health Sciences

DMU Research Centre:

• Research Group affiliations: Biomedical and Environmental (AHS)
  
• Food and Nutrition (HLS)
  
• Grand Challenges Ageing LLHW advisory group (DMU)
  
• Transdisciplinary (DMU)
  

 

 

Contact Details

 

Email: gbasten@dmu.ac.uk

 

Website: http://www.dmu.ac.uk/research/hls/staff/basten.jsp

Twitter: http://twitter.com/grahambasten

Academic Blog: http://isothiocyanates.blogspot.com/

Research Blog: http://grahambastenresearch.blogspot.com/

 

 

Personal Profile: (list or provide an overview containing as many key words about your work/area as possible):

 

"Nutrition: Cells to Communities"

• Clinical Nutrition
  
  • Folate
    
  • Glucosinolates
    
  • Blood test results / pathology
    
  • CVD (homocysteine and vascular tone) and cancer risk (uracil misincorporation)
    
  • Cell culture, clinical chemistry, molecular biology, vascular tone physiology (exercise).
    
  • Added value, product reformulation, fortification, supplementation and functional foods
    

  
   

• Social Nutrition
  
  • Use of validated Food diaries and nutrient analysis
    
  • Access to food and food policy
    
  • Community and school meals
    

 

 

Externally Funded Research Grants Information

Project title, Funding agency, type of project, start date, end date, role in project, collaborators

 

• £40k from 2008 to date
  
• I co-wrote bids for the 3^rd sector East Midlands charity as part of the RIF project and received over £40k from Sport Relief, One Nottingham and the Big Lottery to allow the community group to develop a healthy cookbook and address health and wellness.
  
• 2011 Royal Society Partnership Fund with Crompton School £3,000
  
• 2011 Big Lottery Fund Awards for All with OSCAR Nottingham £11,495
  
• 2010 One Nottingham £4,830 with OSCAR Nottingham
  
• 2010 Comic Relief - core funding for Sickle Cell sufferer support about £28k over 2 years with OSCAR Nottingham
  

 

 

Internally Funded Research Project Information

Project title, Funding source, type of project, Start date, end date, role in project, collaborators

 

• £17k from 2008 to date
  

 

1. DMU RIF: £6k Healthy Building Design (PI), 2009-2010, AHS (HLS), Art and Design and IESD.
   
2. DMU RIF: £3k Food and Nutrition (PI), 2009-2010, AHS, NHS, 3^rd sector charity, local government.
   
3. DMU Teacher Fellow: £2k Technology and learning, (PI) 2010-2011
   
4. DMU Antioxidant Project, £2k, AHS, Pharmacy and Nursing (I), 2008-2009
   
5. DMU TQEF £2k: Moodle vs Blackboard, AHS, (I) 2009
   
6. DMU RITA £2K Virtual Analytical Laboratory, AHS, (I), 2008-2009
   

 

Consultancy/External Income Generation Information:

Area of expertise, previous consultancies undertaken, currently available Y/N, companies worked with.

• Understanding blood test results
  
• Pepsi Co: Working on their wellness programme by reformulating products to contain less sugar and salt.
  
• One Nottingham / Nottingham City Council / Marmot to investigate how social housing, school meals and nutrition effects social aspiration, health and wellness.
  

 

 

 

'Outputs' produced since January 2008 not yet included in DORA

• Book: (Ventus Publishing) Introduction to Clinical Chemistry: Blood Test Results
  
• Book: (Ventus Publishing) Introduction to Scientific Research
  
• Peer reviewed paper: Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Duthie SJ, Horgan G, de Roos B, Rucklidge G, Reid M, Duncan G, Pirie L, Basten GP, Powers HJ. J Proteome Res. 2010 Apr 5;9(4):1941-50
  

  
   

• 'The prevalence of Fusobacterium necrophorum in persistent sore throat swabs: a screening method that is hard to swallow?' (ref 39/10), British Journal of Biomedical Science
  

 

• Comparative effects of a 16-week folate-rich mixed diet versus folic acid intervention and influence of MTHFR C677T genotype on folate status and homocysteine in a 2-centre randomised placebo-controlled study
  Maria J King¹, Anthony Lynn², Caroline A Wolfe¹, Graham P Basten², Gavin Willis³, Anthony J Wright¹, Margo E Barker², Hilary J Powers² and Paul M Finglas¹ Molecular Nutrition and Food Research
  

 

Conference Attendance

Title, dates, location, title of contribution, authors, type of contribution

 

• Conference Abstract: Sickle Cell and Nutritional Health: Can the Type of Food We Eat Help to Reduce the Sickle Cell Crisis? A Discussion About Access to Food Versus Supplementation. International Conference on Health, Wellness and Society - W11R0032 - University of California Berkeley, USA
  
• Conference Abstract: Sickle cell and nutrition: Can the type of food we eat help to reduce the sickle cell crisis? An Invitation to participate in research. Sickle Cell: The Next 100 Years
  
• Conference Abstract: Sickle cell and nutrition: A discussion about food versus folic acid supplement Sickle Cell: The Next 100 Years
  

Honours & Awards

Name of honour / award, month conferred, year conferred, reason conferred

• DMU Teacher Fellow, August 2010, Pedagogy Research.
  

 

Membership of Professional Associations & Societies

Association Name, period start, period end, Description

 

• Member of IBMS 2007-date
  
• Member of Phytochemical Society of Europe 2007-date
  
• Member of Nutrition Society 2000-2008
  
• Fellow of Higher Education Academy
  

 

 

Impact case studies

Examples of evidence of the 'Impact' of research e.g. references to reviews/articles in main stream media, examples of feedback from users, exhibition attendance figures

• Will not have quarterly book sales figures until mid 2011 buy over 754 people "like" them in review.
  
• Citation in numerous review papers
  
• Media:
  
  • http://www.nutraingredients.com/Research/Folic-acid-supplements-could-boost-DNA-repair-says-study
    
  • http://www.knowledgescotland.org/briefings.php?id=53
    
  • Nestle: http://pt.wkhealth.com/pt/re/nestle/abstract.00006705-200411000-00010.htm;jsessionid=M8sLSXCQycGFKXXq24qS2P0zFDQvyQdYvLHp4hVvP7GDjK0Swwnn!-929085697!181195628!8091!-1?nav=reference
    
    
• Policy changes:
  
  • http://ukpmc.ac.uk/abstract/MED/18065205;jsessionid=DDBB70C8B68B7E88E3F4AE6E20152FD5.jvm4
    
  • http://www.eatwell.gov.uk/healthissues/factsbehindissues/folicacid/
    
  • User feedback: References from Chrissie Wells, Oscar, Nottingham
    
  • Specific case study documents could be created in request.
    

 

Evidence of research esteem (RAE)

Graham P Basten joined DMU May 2007 as Senior Lecturer in Clinical Chemistry - Biomedical Sciences, after working at the Medical Schools at the Universities of Sheffield and Nottingham for nearly 7 years. He is now Associate Head of School for Allied Health Sciences.

GP Basten is currently establishing his research group at DMU. He is internationally known for his work on how micronutrients modulate the pathophysiology of disease in the context of early-stage biomarkers in non-invasive surrogate tissue. Immediately prior to DMU he worked with Prof HJ Powers (University of Sheffield) in collaboration with Paul Finglas (Institute of Food Research) on the relationship between folate status and biomarkers of cardiovascular disease, cancer and health. The intervention work looked at food intervention vs supplementation using food diaries, 24 hour recall and clinical makers. In collaboration with Dr SJ Duthie (Rowett Research Institute) he validated biomarkers of DNA instability, showed that folate supplementation elicited a significant reduction in uracil misincorporation in healthy people, and developed an automated method to measure folate in lymphocytes and buccal cells. With Prof SA Watson (University of Nottingham) he showed that hyperplastic polyps have elevated levels of pre-cancerous biomarkers compared with normal resection colorectal samples. In a European Union project co-ordinated by Prof IT Johnson and Prof G Williamson (Institute of Food Research) he investigated the induction of phase II detoxification enzymes (i.e. human bilirubin UDP-glucuronosyl transferase) and apoptosis by glucosinolate derived isothiocyantes. With Prof AJ Knox (Nottingham City Hospital) he elucidated how cGMP modulates nitric oxide levels in asthma and cystic fibrosis patients. He maintains strong links with the collaborators listed above.

 

Evidence of esteem:

He has been invited to speak at a number of international and national meetings (i.e. 6th Winter Research Conference on Free Radicals, France (2003), the 15th International Symposium on Regulatory Peptides, Toulouse, France (2004), the Nutrition Society Meeting 2005 and helped to organise the Nutrition Society Meeting 2001, and the Sheffield Teaching Hospitals Trust Cancer Research Away Day). He was co-author on a comprehensive review of folate, DNA stability and colo-rectal neoplasia (Proc. Nutr. Soc. 2004;63(4):571-8). Media dissemination to BBC Radio Sheffield, local and national press, and worked with the current premiership squad of Sheffield United Football Club. Prior to joining DMU he has co-written several successful external grants (i.e. Food Standards Agency (FSA) 460K, completed 8 months ahead of schedule, World Cancer Research Fund (WCRF) 240K) and submitted grants with novel collaborations (i.e. National Institutes of Health USA, collaboration with Anderson Cancer Centre, USA, and the Royal Society Pump Priming Award, collaboration with the Dept. of Architecture, University of Sheffield). Based on previous work, submissions and collaborations he anticipates potential funding for future research at DMU from the FSA, WCRF, CORE, EU and BBSRC.

DMU/OSCAR Food Manual

OSCAR Nottingham and Dr Graham Basten (DMU) have written a Food Manual with exciting recipes and a whole range of hints, tips and information about healthy and economic shopping, cooking and eating. If you are interested in purchasing a copy, please contact us: http://oscarnottingham.org/Index.aspx

The urgent news is that we are launching the Food Manual on Friday 6th May - this is to gather opinion from the public about holistic health including diet and nutrition and there will be health stalls and some speakers including a local GP. It's very short notice but if you can drop in it would be great.

It is from 10 am to 4 pm at the Elohim Community Centre on the Wells Road, near Hendon Rise (parking off Hendon Rise), Nottingham

Ismaili Nutrition Launch

Brilliant networking at the Midlands Launch of the Aga Khan Health Board's Ismaili Nutrition Centre.

This work closely replicates the nutrition work I am doing at DMU, we have been collecting data on the nutritional profile of foods from South Asian, African, Caribbean and undergraduate cohorts in the East Midlands.

Sickle Cell Meeting

Great discussion between Graham Basten and Sharon Cox. Talking about sickle cell research at DMU, SCOOTER LSHTM, Tanzania and KEMRI. Discussed some exciting potential research and training potential.

Research activity

• Royal Society Partnership Grant with Crompton View School
• Art and Design Project to look at stress
• Member of transdiscipline group at DMU
• Member of DMU Connected Communities Bid Team,

More information to follow...!

School Foods: Healthy Children, Healthy Minds

I recently attended the School Foods: Healthy Children, Healthy Minds event at the Royal Society.

There were some excellent speakers on this difficult and interesting topic

Possible new link

Great work being done by Ify in the states

http://www.choa.org/default.aspx?id=2210

RIF Showcase

I presented an oral presentation and poster at DMU's RIF Showcase for the two projects that I have been PI.

The DMU Revolving Investment Fund (RIF) Showcase

From pilot studies into new textile technologies to research collaborations with China and exhibitions by British sculptors, come and discover more about this years latest RIF funded research projects.

Friday 17 September 2010. Queens Building, 10.00 – 14.00 (inc lunch)

Twenty two projects were supported by the fund from January to July 2010. Each project varied in scope from developing new communities for future research collaborations to pilot studies to support future research council grant applications. The event will showcase all the RIF projects and presents an opportunity to view the newer, innovative aspects of DMU research. This is also chance to meet and interact with researchers from across the University.

The event begins at 10:00 am with a short series of talks from a number of the projects followed by a poster session, the lunchtime session will provide an excellent opportunity to network with the all the researchers involved.

Health Literacy

The health literacy and JISC sites may be an option for some interesting TEL research.

EU Funding

Following my meetings with Nottingham City Council, we are looking at future calls and tenders.

Future themes and challenges

Here are my thoughts on future themes, concerns, research areas or developments important to food science and human nutrition:

1. Fortification of food: Should the state intervene by recommending the fortifications of food for public health, for example folic acid?

2. Functional foods: Foods high in phytochemicals and other nutrients which are increasingly being seen as beneficial often attract a premium price and some claims which may be ambitious. The science is needed to back up these claims, studies done on humans.

3. Additional uses: The food industry is crossing boundaries to now have nutrients for example in cosmetics or medical procedures.

4. Self regulation vs state regulation: Product reformulation consumer driven by economics or regulated by the state, for example salt content.

5. Food deserts: Certain cohorts are excluded from fresh fruit and vegetables due to low car ownership, poor public transport and location top shopping areas and markets which increasingly are in more affluent areas.

6. School meals and education: This dichotomy is key to reducing rates of obesity and diabetes. Children and young adults must be fed a healthy and sustainable diet at school and college and be taught the basics of nutrition such as reading food labels, what is fat, how to shop and how to put a meal together.

7. Media and Science: Generally the public’s perception and understanding of Science is low. The overall message of health and nutrition is lost by continual scare stories and bad Science.

PEPSICO

Case Study

PepsiCo Health Report 2010

Graham Basten (GB*) from De Montfort University (DMU) participated in the creation of the PepsiCo Health Report hosted by C3 and Oxford HealthCare Alliance. The report sought to expand on self regulation of the company through product reformulation and sustainability. With the exception of the University of Reading, GB was the only other representative from academia. The series of events highlighted and frame worked discussions which were highly relevant given the new Secretary for Health’s (Andrew Lansley MP) policy statements on the regulation of the food industry.

*GB holds a PhD from the UK government’s Institute of Food Research and clinical nutrition research experience at the Medical Schools of the Universities of Nottingham and Sheffield, with the latter being funded by the Food Standards Agency. Much of this work was reducing risk of heart disease and cardiovascular disease, one of the Department of Health’s top 5 priorities.

AMR Grant

We have just submitted a research grant to look at sickle cell and diet to the AMR charity.

Hope PhD

We have submitted a PhD application looking at early stage markers for colon cancer to the HOPE charity.

DMU Research Advisory Groups: Longlife Health and Wellbeing

I am a member of the DMU Grand Challenges Research Advisory Groups: Longlife Health and Wellbeing.

CURRENT RESEARCH: Prior to joining DMU in 2007 I enjoyed over ten years post-doctoral research at the UK Government’s Institute of Food Research, The University of Sheffield and Nottingham Medical Schools and co-authoring over £1.5 million research grants. My research expertise spans from the molecular biology, to the food and nutrition, to the community in which people live, to the policy which governs these. All the Grand Challenge statements identified above will be served by these research activities

DMU RIF: In collaboration with Oscar (3^rd Sector East Midlands Charity) / Action Medical Research/ NHS to investigate molecular, nutrition and social solutions to sickle cell disease using novel research techniques. DMU RIF: In collaboration with Faculty of Art and Design, IESD and NHS to investigate the effect of the built environment of health and wellness. Pepsi Co: Working on their wellness programme by reformulating products to contain less sugar and salt. One Nottingham / Nottingham City Council / Marmot to investigate how social housing, school meals and nutrition effects social aspiration, health and wellness. HOPE Cancer Charity application to study the effect of food in Leicestershire and Rutland on cancer risk using novel techniques Trial manager for UK Food Standards Agency / World Cancer Research Fund previous work to study the effect of nutrition of cancer and heart disease in large multicentre human intervention studies. FreshGrow are a major East Midland’s vegetable grower with whom I have links and projects with and help to link the food at source to our molecular work. University of Leeds collaboration to measure photochemical activity in ethnic foods in Leicester

BENEFIT FROM NETWORK: Networking and collaborative opportunities; Access to review documents, grant calls, support network; Bring my research knowledge and expertise to the network; Shape DMU research policy and apply to School as I am Associate Head of School

Interests: Factors that influence health and wellbeing; Effective quality of life interventions Improving quality of life at all levels; Informing policy and practice

Marmot Review

Dear Stakeholder,

Last week, Professor Sir Michael Marmot was appointed President of the British Medical Association (BMA). His term will run from June 2010 to June 2011. In this role he will continue to champion tackling health inequalities through the social determinants with particular emphasis on developing the role of the workforce in reducing health inequalities.

Appearing on a number of BBC programmes on Friday morning, Professor Marmot responded to the National Audit Office's report on health inequalities (which was published last week) explaining why health inequalities are not narrowing. Listen to Michael's interview with the BBC Today programme here .

The new website is now online and can be found at www.marmotreview.org . Here you will find all the information previously available on the old websites, as well as pages about our present and past activities and events, press releases, and news coverage. Presentations from the launch conference are available on the website, and graphs from the report can be found on the Presentations page as well. There is also a section on the European Review, still in its early stages.

The website should enable us to more easily interact with stakeholders and anyone else interested in the issue of health inequalities. We would like to hear from you about any interventions, activities or strategies you are implementing locally, and how they are going. This will help us to develop more of an idea of what works.

We would be grateful if you could forward this information to interested colleagues and relevant networks.

Kind Regards,

Ellen

Ellen Bloomer

Research Fellow

The Marmot Review